Search results for "C [POLY I]"
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Filipinas en el marco del imperio español en el siglo XIX
2019
[EN] En este artículo se analiza la evolución de Filipinas en las últimas décadas del siglo XVIII y en el transcurso del siglo XIX a través de diferentes epígrafes: la obligada transformación del secular modelo colonial volcado hacia el tráfico del Galeón y las relaciones transpacíficas; la renovada inclinación hacia Asia, el océano Índico y el mar de China; el desarrollo de un sistema económico basado en la exportación de productos filipinos y en la apertura de las islas al exterior; la evolución de la vida política; el camino hacia la modernización; el peso de las órdenes religiosas, la importancia de la población china y la colaboración con élites indígenas como rasgos singulares de Fili…
Roland Barthes. El sentido de la moda
2021
Roland Barthes devoted much of his intellectual interest to the phenomenon of fashion. Long before his famous Système de la Mode, he wrote numerous essays on the subject, mainly of a methodological nature, both to elaborate a coherent historiography of dress and to establish a semiology of dress itself, distinguishing –with Saussure– between costume (langue) and clothing (parole). Indeed, if dress is a heteroclite whole, like language for Saussure, the semiologist’s task is to reconstruct its functioning as a system of signs, not only in the dress described by the magazines (as he does in Système), but also in the dress actually worn. A set of essays, in short, of extreme importance for any…
Ruch ludowy w Drugiej Rzeczypospolitej na kartach wybranych szkolnych podręczników do nauczania historii. Casus opracowań dla klas pierwszych szkół p…
2021
The purpose of this article is to present the peasant movement in the Second Polish Republic in contemporary school history textbooks. On the basis of textbooks, students can learn that the peasant movement arose in Galicia in the late nineteenth century. In the Second Polish Republic there were a few parties named Polish People’s Party. For many years the main party was Polish Peasant party ,,Piast”. After Poland regained independence in 1918, it formed a part of several governments, most notably after the Lanckorona Pact and in the Chjeno-Piast coalition. Its major politicians included Wincenty Witos and Maciej Rataj. The second largest party, about which there is a lot of information in …
Grzech pierworodny w kontekście ewolucyjnego obrazu świata
2021
Modern science portrays the genesis of man as just another link in the chain of evolution - first cosmic and then biological evolution. In such a worldview there is no place for a Garden ofEden or a miraculously innocent couple. Also, violence, suffering and death have accompanied humanity from the very be�ginning. The aim ofthis paper is to show that the Christian doctrine oforiginal sin does not conflict with the scientific worldview, provided, however, that it is properly understood. Within the evolutionary model ofthe world, original sin can be defined as the refusal to take a certain step that at some point should have been taken and that was made possible by Gods call. The failure to …
Transgresywny charakter pisarstwa w polu teorii polityki
2023
Tezą niniejszej artykułu jest twierdzenie, iż specyficzną cechą pisarstwa w dziedzinie teorii polityki jest jego trangresywność, a więc przekraczanie niektórych norm. Oznacza to, że podejmuje ono polemikę z wzorcem naukowości, który wyraża się w formalnych regułach, stanowiących aktualne kryterium naukowości. Obranie perspektywy teorii polityki, inspirowanej dorobkiem Pierre’a Bourdieu, pokazuje, że przyjęta definicja nauki jest kluczową stawką w grze toczonej na polu nauki, w tym na „subpolu” teorii polityki. Celem artykułu jest pokazanie, iż transgresywny charakter piśmiennictwa teoriopolitycznego nie stawia go poza naukowością, lecz jest formą negocjacji samych norm naukowości poprzez pr…
Heat Shock Protein 60 in Hepatocellular Carcinoma: Insights and Perspectives
2020
Heat shock protein 60 (HSP60) is a mitochondrial chaperone that is implicated in physiological and pathological processes. For instance, it contributes to protein folding and stability, translocation of mitochondrial proteins, and apoptosis. Variations in the expression levels of HSP60 have been correlated to various diseases and cancers, including hepatocellular carcinoma (HCC). Unlike other HSPs which clearly increase in some cancers, data about HSP60 levels in HCC are controversial and difficult to interpret. In the current review, we summarize and simplify the current knowledge about the role of HSP60 in HCC. In addition, we highlight the possibility of its targeting, using chemical com…
Metabolic Reprogramming of Innate Immune Cells as a Possible Source of New Therapeutic Approaches in Autoimmunity.
2022
Immune cells undergo different metabolic pathways or immunometabolisms to interact with various antigens. Immunometabolism links immunological and metabolic processes and is critical for innate and adaptive immunity. Although metabolic reprogramming is necessary for cell differentiation and proliferation, it may mediate the imbalance of immune homeostasis, leading to the pathogenesis and development of some diseases, such as autoimmune diseases. Here, we discuss the effects of metabolic changes in autoimmune diseases, exerted by the leading actors of innate immunity, and their role in autoimmunity pathogenesis, suggesting many immunotherapeutic approaches.
Estudio del mecanismo de reacción e inhibición de cisteína proteasas mediante métodos multiescala
2022
En esta tesis doctoral se realizaron estudios computacionales para las enzimas caspasa-1 y la 3CLpro del SARS-CoV-2. Estas enzimas pertenecen a la familia de las cisteína proteasas, las cuales hidrolizan sus respectivos sustratos rompiendo un enlace peptídico en particular. En esta reacción interviene una diada catalítica conformada por un par Cis-His. La caspasa-1 fue seleccionada debido a su importancia farmacológica en la enfermedad de Alzheimer, y la enzima 3CLpro del SARS-CoV-2 por estar involucrada en el proceso de replicación del virus responsable de la enfermedad del COVID-19. Para ambas se realizaron estudios que ayudaron a racionalizar el mecanismo de reacción con su sustrato natu…
The (im)possible success of disadvantaged students. Reflections on education, migration and social change
2019
The paper focuses on the ?unexpected pathways? of successful students with an immigrant background: these biographical routes, that seems socially impossible, raise theoretical issues around the individual-society, actor-structure relationship. Disadvantaged students who succeed represent a sociological challenge in the attempt to understand atypical situations and to identify the institutional processes and the structural opportunities that facilitate them, reducing ethnic inequalities in education. This framework is the starting point of the Su.Per. project (Success in educational pathways of students with immigrant background), based on the collection of written autobiographies of 65 imm…
Thiazole Analogues of the Marine Alkaloid Nortopsentin as Inhibitors of Bacterial Biofilm Formation
2020
Anti-virulence strategy is currently considered a promising approach to overcome the global threat of the antibiotic resistance. Among different bacterial virulence factors, the biofilm formation is recognized as one of the most relevant. Considering the high and growing percentage of multi-drug resistant infections that are biofilm-mediated, new therapeutic agents capable of counteracting the formation of biofilms are urgently required. In this scenario, a new series of 18 thiazole derivatives was efficiently synthesized and evaluated for its ability to inhibit biofilm formation against the Gram-positive bacterial reference strains Staphylococcus aureus ATCC 25923 and S. aureus ATCC 6538 a…